Older Male with Small Mobile Mass Near Left Epididymis

Deloar Hossain, M.D.

Specimen Type:

Epididymis

History:

Cellular angiofibroma is a rare soft tissue tumor of the paratesticular region. Less than 2 dozen cases are reported in the literature. Literature review shows this tumor has a benign outcome with a very rare case with local recurrence (Ref-1).

Pathologic Features:

Gross Features:A 1.2 cm oval tan soft to rubbery mass was received and submitted for histological examination.

Microscopic Features: The tumor is composed of tapered spindled cells proliferating between numerous small to medium-sized vessels (fig 1, 2, 3, 4). Focal epithelioid-appearing stromal cells were seen. No Mitotic activity seen. Tumor cells exhibits immunoreactivity for vimentin (fig 5), muscle-specific actin(fig 6), and smooth muscle actin (fig 7). All other immunostains are negative, including progesterone receptor protein, estrogen receptor protein, CD34, desmin, and S-100 protein.

Differential Diagnosis:

  • Leiomyoma
  • Postoperative Spindle Cell Nodule
  • Inflammatory Myofibroblastic Tumor
  • Solitary Fibrous Tumor
  • Granular cell tumor

Diagnosis:

Cellular aggiofibroma.

Cellular angiofibroma is a rare soft tissue tumor of the paratesticular region.

Less than 2 dozen cases are reported in the literature. Literature review shows this tumor has a benign outcome with a very rare case with local recurrence (Ref-1).

References:

  1. Laskin WB, Fetsch JF, Mostofi FK.Angiomyofibroblastomalike tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 1998 Jan;22(1):6-16.